Human chromosome 21 gene function and pathway database
with knowledge discovery tools

Recent publications from the Gardiner laboratory

 

Nguyen CD, Gardiner KJ, Cios KJ. Protein annotation from protein interaction networks and Gene Ontology. J Biomed Inform. 2011 May 6 [Epub ahead of print].

Nguyen CD, Cios KJ, Gardiner, KJ. (2011) Machine Learning Methods predict locomotor response to MK-801 in mouse models of Down syndrome, J Neurogenetics, 25(1-2):40-51.

Sturgeon X, Gardiner K. (2011) Comparative Transcript Catalogs of Human Chromosome 21 and Orthologous Chimpanzee and Mouse Genomic Regions, Mam Genome, 22:261-71.

Ahmed M, Gardiner K. (2011) Preserving protein profiles in tissue samples: differing outcomes with and without heat stabilization. J Neurosci Methods. 2011 196:99-106.

Nguyen CD, Gardiner KJ, Nguyen DT, Cios, KJ. (2010) A framework for Multiple Instance Learning. IEEE Proceedings of Internat Soc Data Algo 2010.

Gardiner KJ, Herault Y, Lott IT, Antonarakis SE, Reeves R, Dierssen M. (2010) Down Syndrome: From Understanding the Neurobiology to Therapy, J Neurosci. 30:14943-14945.

Gardiner K. (2009) Pharmacotherapies for cognition in Down syndrome, Trends in Pharm Sci, 32:66-73.

Le T, Altman T, Gardiner K. (2009) HIGEDA: A hierarchical gene-set genetics based algorithm for finding subtle motifs in biological sequences. Bioinformatics, 26:302-309.

Siddique A, Lacroix T, Stasko M, Costa AC, Gardiner K. (2008) Molecular response of the Ts65Dn and Ts1Cje mouse models of Down syndrome to the NMDA receptor antagonist, MK-801, Genes, Brain Behav 7:810-819.

Kuhn DE, Nuovo GJ, Martin MM, Malana GE, Pleister AP, Gardiner K, Terry Jr AV, Head E, Lott L, Elton TE, Feldman DS. (2008) Chromosome 21-derived mir-155 provides an etiological basis for aberrant protein expression in Down syndrome brain. Biochem Biophys Res Commun 370:473-477.

Nikolaienko O., Nguyen C., Crnic L. S., Cios K. and Gardiner K. (2005) Human chromosome 21/Down syndrome gene function and pathway database. Gene, 364, 90-98

Gardiner K. (2004) Gene dosage effects in trisomy. Genome Biology 5:244

Gardiner K, Davisson MT and Crnic LS (2004) Building protein interaction maps for Down syndrome. Briefings Funct Genom Proteom 3:142-156.

Tsyba L, Skripkina I, Rynditch A, Nikolaenko O, Fortna A, Gardiner K. (2004) Alternative splicing of mammalian Intersectin 1: domain associations and tissue specificities. Genomics 84:106-13.

Gardiner K. (2003). Predicting pathway perturbations in Down syndrome. (2003) J Neural Transm 67:21-37.

Gardiner K, Fortna A, Bechtel L and Davisson M. (2003). Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions. GENE 318:137-147.

Slavov D and Gardiner K. (2002) Phylogenetic comparisons of the ADAR2 RNA editases: gene structures, editing and alternative splicing. Gene 299:8-9.



Recent publications from the Cios laboratory

 

Nguyen C., Gardiner K. and Cios K.J. 2007. Hidden Markov Model for Prediction of Protein Interfaces. Journal of Bioinformatics and Computational Biology, 5(3):739-753

Swiercz W.,Cios K.,Hellier J.,Yee A.,Staley K. 2007 Effects of Synaptic Depression and Recovery on Synchronous Network Activity. J Clin Neurophysiol, 24, 165-174

Homaeian L., Kurgan A.K., Ruan J., Cios K.J. and Chen K. 2007. Prediction of Protein Secondary Structure Content for the Twilight Zone Sequences. Proteins, DOI: 10.1002/prot.21527

Tripet B., RenukaJayadev M., Blow D., Nguyen C., Hodges R. and Cios K.J. 2007. Proteomic Data Mining Using Predicted Peptide Chromatographic Retention Times. International Journal of Bioinformatics Research and Applications, 3(3): in print

Lovelace J. and Cios K.J. 2007. A Very Simple Spiking Neuron Model that Allows for Efficient Modeling of Complex Systems. Neural Computation, (19):1-26

Cios K., Kurgan L. and Reformat M. 2007 Machine Learning in the Life Sciences. IEEE Engineering In Medicine And Biology Magazine, 26(2), 86-93

Schuyler R.,White A., Staley K. and Cios K. 2007 Epileptic seizure detection. IEEE Engineering In Medicine And Biology Magazine, 26(2), 86-93

Nguyen C., Thaicharoen S., Lacroix T., Gardiner K. and Cios K. 2007. A Comprehensive Human Chromosome 21 Database. IEEE Engineering In Medicine And Biology Magazine, 26(2), 86-93

Sun S., Meyer-Arendt K., Eichelberger B., Brown R., Yen CY, Old W, Pierce K, Cios KJ, Ahn N and Resing K. 2007 Improved Validation of Peptide MS/MS Assignments Using Spectral Intensity Prediction. Molecular & Cellular Proteomics, 6(1):1-17

Balasubramanian N., Wilson B.J. and Cios K.J. 2006. Innovative Methods of Teaching Science and Engineering in Middle Schools. Journal of Systemics, Cybernetics and Informatics, 4(6), http://www.iiisci.org/Journal/SCI/Contents.asp

Siebert J., Newell K., Villa-Lobos E. and Cios K.J. 2006 A rich analytical environment for flow cytometry experimental results. Int. J. Bioinformatics Research and Applications, 2(1), 52-62

Yen CY., Russell S., Mendoza A., Meyer-Arendt K., Sun S., Cios K.J.,Ahn N. G. and Resing K. 2006 Improving Sensitivity in Shotgun Using a Peptide-Centric Database with Reduced Complexity: Protease Cleavage and SCX Elution Rules from Data Mining of MS/MS Spectra. Analytical Chemistry, 78(4):1071-84

Swiercz W., Cios K.J., Staley K., Kurgan L., Accurso F. and Sagel S. 2006  New Synaptic Plasticity Rule For Networks Of Spiking Neurons, IEEE Transactions on Neural Networks, 17(1):94-105

Kurgan L., Cios K.J. and Scott D. 2006. Highly Scalable and Robust Rule Learner: Performance Evaluation and Comparison. IEEE Transactions Systems Man And Cybernetics, part B, 36(1):32-53

Nikolaienko A., Nguyen C., Crinc L., Cios K.J. and Gardiner K. 2005 Human chromosome 21/Down syndrome gene function and pathway database. Gene, 364: 90-98.

Hamady M., Cheung T., Resing K., Cios K.J. and Knight R. 2005 Key Challenges in Proteomics and Proteoinformatics. IEEE Engineering in Medicine and Biology Magazine, 24(3):34-40.